The Mystery of #Microcephaly in Brazil :Questions unanswered.

While we are observing an after-peak of Zika cases in Colombia and expecting no longer to reach 600.000 despite stats predictions, what is going on in Brazil and what do we know as of today about Zika virus and its pathogenesis?

What has been confirmed from In vitro studies?

  1. Zika virus crosses placenta barriers;
  2. Zika virus crosses blood-brain barrier;
  3. Zika virus can infect fetus;
  4. Zika virus has neurotropism;
  5. Zika virus is responsible for:
    • Guillain-Barré Syndrome (GBS)
    • Myelitis
    • Encephalitis
  6. Zika virus is linked with microcephaly during the Q1 of pregnancy.

Colombia_Zika_Report#9When comparing Brazil/Colombia at the time being, meaning with some delay in the observance of microcephaly due to later spread of Zika virus in Colombia, on 61.393 suspected cases, 11.239 pregnant, zero microcephaly recorded so far in this cohorte but Colombia has identified 50 microcephalies, under investigation, of which only 7 under review for Zika virus while waiting for 25 (half of the cohorte) final results. We would be close to 2/10.000 prevalence or less with regards microcephaly related to Zika virus…more or less the historical prevalence of microcephaly in Brazil (26 times above in 2016).

Questions remaining without answer:

  1. Has Zika virus mutated since arrival in Americas/Brazil?
  2. Is there possible co-infection:
    • with Dengue?
    • with CMV, Rubella?
  3. Is there possible dual cause:
    • with a chemical?
    • with larvicide, pesticide?
    • with Global Health issues (environment,Socio-economics)?

In a previous blog, we pointed out the choice of Colombia as a control group for the prevalence of microcephaly in link with Zika virus in order to answer the question about Zika virus as causative microcephaly.

So May we confirm, as WHO and CDC are delivering statement, that microcephaly is definitively related to Zika virus? More evidence required by answering questions.

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